Subcellular scaling: does size matter for cell division?

Controlling cell division in yeast and animals: does size matter?

In yeast, cell-size checkpoints coordinate cellular growth with cell-cycle progression. Now, evidence has been provided that such checkpoints probably do not exist in mammalian cells. These findings highlight an important difference between how yeast and animal cells proliferate in response to extracellular cues.

Does size matter? Clinical applications of scaling cardiac size and function for body size.

Extensive evidence is available that cardiovascular structure and function, along with other biological properties that span the range of organism size and speciation, scale with body size. Although appreciation of such factors is commonplace in pediatrics, cardiovascular measurements in the adult population, with similarly wide variation in body size, are rarely corrected for body size. In thi...

The sinoatrial node: cell size does matter.

Merkel Cell Carcinoma: When Does Size Matter for Radiotherapy?

Merkel cell carcinoma is a very aggressive, rare cancer of the skin. It has a high propensity for local, regional, and distant recurrence and has recently been associated with a viral etiology from the recently diagnosed Merkel Cell Polyoma Virus. The optimal management remains controversial. We discuss the case of a man with a 26 cm axillary lymph node metastasis of unknown primary treated wit...

Does size matter ?

Body size is a key parameter influencing demographic characteristics of fish populations as well as market value of landed catch. Yet in bioeconomic modelling body size is often an overlooked biological and economic parameter. Here we evaluate how sizedependent pricing influences optimal harvest strategies in a model parameterized for two pelagic fisheries, those targeting Atlantic herring (Clu...